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Table 4 Model calibrated parameters with description and simulation values

From: A novel process-based model of microbial growth: self-inhibition in Saccharomyces cerevisiae aerobic fed-batch cultures

Symbol Description Unit Calibration starting value Calibrated values
LBG H 1022a CBS 8066b CEN.PK113-7Dc CEN.PK2-1Cd
v G Maximum uptake rate h−1 3.64 [54] 3.3 5.1 5.8 5.8
k G Uptake saturation constant g l−1 0.18 [55] 0.2 0.2 0.27 0.27
η G Uptake efficiency P/G 0.92 [56] 0.76 0.76 0.86 0.64
v RP Maximum glycolysis products respiration rate h−1 0.475 [57] 1.5 0.67 1.0 0.83
k RP Glycolysis products respiration saturation constant g l−1 0.033–0.035 [58] 0.24 0.21 0.24 0.18
η RP Respiration efficiency C M /P 0.6 [56] 0.80 0.80 0.80 0.73
v F Maximum fermentation rate h−1 11.8 [57] 3.3 4.17 2.6 6.57
k F Fermentation saturation constant g l−1 0.5 [59] 0.13 0.18 0.14 0.16
η FE Fermentation efficiency E/P 0.47 [60] 0.595 0.80 0.60 0.61
η FP Fermentation efficiency C M /P 0.09 [61] 0.13 0.16 0.20 0.10
v RE Maximum ethanol respiration rate h−1 0.19 [11] 0.20 0.14 0.20 0.11
k RE Ethanol respiration saturation constant g l−1 0.1 [13] 0.12 0.12 0.15 0.15
η RE Respiration efficiency C M /E 0.68 [62] 0.65 0.55 0.80 0.80
v A Maximum accumulation rate h−1 0.2 (Arbitrary) 0.2 0.2 0.2 0.3
k A Accumulation saturation constant g l−1 0.05 (Arbitrary) 0.05 0.05 0.05 0.03
η A Accumulation efficiency R/P 0.2 (Arbitrary) 0.2 0.2 0.2 0.2
r MAX Maximum reserves/cell mass ratio 0.25 [63] 0.3 0.3 0.3 0.3
δ Death rate h−1 0.017–0.032 [27] 0.05 0.05 0.05 0.1
τ Death threshold g l−1 0.6 (Arbitrary) 0.6 0.6 0.6 0.6
ρ Secretion rate h−1 0.01 (Arbitrary) 0.01 0.01 0.01 0.02
σ I Sensitivity to inhibitor NF 1.0 (Arbitrary) 1.0 1.0 1.0 1.68
σ E Sensitivity to ethanol NF 1.4 [49, 64, 65] 1.4 1.4 1.4 1.4
c Cell volume/dry weight ratio l g−1 0.01 [66] 0.01 0.01 0.01 0.01
a Metabolic switches calibration parameter 2.0 × 10−4 (Arbitrary) 2.0 × 10−4 2.0 × 10−4 2.0 × 10−4 2.0 × 10−4
b Metabolic switches calibration parameter l g−1 30 (Arbitrary) 30 30 30 30
l 1 Lag phase calibration parameter 0.58 (Arbitrary) 0.58
l 2 Lag phase calibration parameter 2.0 × 10−5 (Arbitrary) 2.0 × 10−5
l 3 Lag phase calibration parameter h−1 5.8 (Arbitrary) 5.8
[P] MAX Glycolysis products maximum concentration g l−1 1 [67, 68] 1 1 1 1
[E] MAX Ethanol maximum concentration g l−1 100 [65] 100 100 100 100
[I] MAX Inhibitor maximum concentration g l−1 1 (Arbitrary) 1 1 1 1
  1. avon Meyenburg [53]; Fig. 2.
  2. bPham et al. [12]; Fig. 3.
  3. cFigure 4.
  4. dFigures 5, 6 and 7.