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Figure 1 | Microbial Cell Factories

Figure 1

From: Redox engineering by ectopic expression of glutamate dehydrogenase genes links NADPH availability and NADH oxidation with cold growth in Saccharomyces cerevisiae

Figure 1

Schematic representation of some yeast NADH- and NADPH-dependent reactions and pathways cited in the text. Adh1-3 alcohol dehydrogenase, Gpd1 glycerol-3-phosphate dehydrogenase, Gre3 aldose reductase, Nde1,2 external NADH dehydrogenase, Ndi1 internal NADH dehydrogenase, AcCoA acetyl coenzyme A, EtOH ethanol, DHAP dihydroxy acetone phosphate, G3P glycerol 3-phosphate, MG methylglyoxal. Note that the glutamate dehydrogenase isoenzyme Gdh2 usually catalyzes the catabolic reaction from l-glutamate to α-ketoglutarate. Nevertheless, when overexpressed [21] or when NH4 + is plentiful [22], contributes to the glutamate production using NADH as cofactor [19]. For other details see the text.

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Microbial Cell Factories

ISSN: 1475-2859

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