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Figure 4 | Microbial Cell Factories

Figure 4

From: Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis

Figure 4

FMO2 based biotransformations of benzydamine. a Whole-cell conversions of benzydamine employing E. coli catalysts based on FMO2*1 and truncations thereof. The conversions were conducted with whole cells corresponding to 15 OD600 units and 1 mM benzydamine for 4 h (hatched bars) and 16 h (filled bars), respectively. Values are shown as mean ± SD of measurements performed in triplicates. Cells carrying the empty vector served as negative control (pMS470). b Reaction scheme of the FMO2 catalyzed benzydamine oxidation. The corresponding N-oxide was identified as product by NMR (see Additional file 1).

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