Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics

Table 2 Growth characteristics and glucose uptake

Strain	YNB + Gluc	μ_MAX	Y_X/S	Glucose uptake
Strain	YNB + Gluc	μ_MAX	(g DCW/g glucose)	(mmol/g DCW/h)
TY757		0.168 ± 0.021	0.0041 ± 0.0003	94.2 ± 14.0
TY920		0.162 ± 0.035	0.0040 ± 0.0004	88.9 ± 38.9
TY952		0.161 ± 0.030	0.0038 ± 0.0003	94.0 ± 21.1
TY985		0.163 ± 0.021	0.0038 ± 0.0004	121.3 ± 30.9
TY1018		0.170 ± 0.024	0.0038 ± 0.0005	120.6 ± 40.0
TY954		0.167 ± 0.017	0.0037 ± 0.0010	105.3 ± 23.5
TY1040		0.061 ± 0.019	0.0024 ± 0.0004	55.6 ± 18.2
TY1040	w/ Met	0.088 ± 0.008	0.0025 ± 0.0005	60.4 ± 18.9
TY1032	w/ Met	0.059 ± 0.004	0.0035 ± 0.0005	61.6 ± 15.5
TY1041		0.072 ± 0.006	0.0024 ± 0.0001	100.2 ± 34.8
TY1041	w/ Met	0.089 ± 0.018	0.0022 ± 0.0002	70.7 ± 23.1
TY1031	w/ Met	0.080 ± 0.011	0.0033 ± 0.0002	57.8 ± 14.6

ISSN: 1475-2859