Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

Table 2 The least-squares fit and coefficient estimate

Variables	Coefficient estimate	Standard error	t -value	p -value
Intercept	636.193	10.156	62.644	0.000
X ₁	−84.799	6.219	−13.635	0.000
X ₂	76.810	6.219	12.351	0.000
X ₈	−66.059	6.219	−10.622	0.000
X ₁ ²	−65.210	9.154	−7.124	0.001
X ₂ ²	−64.543	9.154	−7.051	0.001
X ₈ ²	−35.500	9.154	−3.878	0.012
X ₁ X ₂	1.500	8.795	0.171	0.871
X ₁ X ₈	−29.442	8.795	−3.348	0.020
X ₂ X ₈	−5.105	8.795	−0.580	0.587

ISSN: 1475-2859