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Table 1 The design of experiments and response of FDM A production

From: Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

Run

Soluble starch

Glucose

KH 2 PO 4

FDM A titer ( Y , mg/L)

X 1

X 2

X 8

1

−1

−1

0

531.49 ± 5.21

2

−1

1

0

675.39 ± 20.00

3

0

1

−1

684.50 ± 8.08

4

1

−1

0

334.49 ± 19.05

5

0

1

1

548.14 ± 9.34

6

0

0

0

633.26 ± 17.38

7

0

0

0

637.19 ± 8.79

8

1

1

0

484.39 ± 3.57

9

0

−1

−1

513.95 ± 6.54

10

1

0

1

364.40 ± 4.06

11

0

−1

1

398.01 ± 7.40

12

1

0

−1

533.37 ± 3.95

13

0

0

0

628.13 ± 10.49

14

−1

0

1

578.48 ± 8.97

15

−1

0

−1

647.68 ± 8.08