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Figure 1 | Microbial Cell Factories

Figure 1

From: Increased production of inosine and guanosine by means of metabolic engineering of the purine pathway in Ashbya gossypii

Figure 1

Simplified schematic representation of the de novo purine pathway in A. gossypii. Abbreviations used: ADE4 phosphoribosylpyrophosphate (PRPP) amidotransferase, ADE12 adenylosuccinate synthase, IMD3 IMP dehydrogenase, GUA1 GMP synthase and PNP1 purine nucleoside phosphorylase. The geometric shapes indicate the reactions for which the simulations using the genome-scale metabolic model iRL766 predicted an increase in the metabolic flux upon optimization of the production of biomass, guanosine and inosine (triangles, squares and pentagons, respectively).

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Microbial Cell Factories

ISSN: 1475-2859

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