Table 1 List of genes involved in the mevalonate and ergosterol biosynthesis pathways
Gene | Discription |
|---|---|
The mevalonate biosynthesis pathway | |
ERG10 | Acetyl-CoA C-acetyltransferase (EC:2.3.1.9) |
ERG13 | Hydroxymethylglutaryl-CoA synthase (EC:2.3.3.10) |
HMG1/2 | Hydroxymethylglutaryl-CoA reductase (EC:1.1.1.34) |
ERG12 | Mevalonate kinase (EC:2.7.1.36) |
ERG8 | Phosphomevalonate kinase (EC:2.7.4.2) |
ERG19 | Diphosphomevalonate decarboxylase (EC:4.1.1.33) |
IDI1 | Isopentenyl-diphosphate delta-isomerase (EC:5.3.3.2) |
ERG20 | Bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase (EC:2.5.1.10) |
The ergosterol biosynthesis pathway | |
ERG9 | Squalene synthase (EC:2.5.1.21) |
ERG1 | Squalene monooxygenase (EC:1.14.13.132) |
ERG7 | Lanosterol synthase (EC:5.4.99.7) |
ERG11 | Lanosterol demethylase (EC:1.14.13.70) |
ERG24 | C-14 sterol reductase (EC:1.3.1.70) |
ERG25 | Methylsterol monooxygenase (EC:1.14.13.72) |
ERG26 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC:1.1.1.170) |
ERG27 | 3-keto-steroid reductase (EC:1.1.1.270) |
ERG6 | Sterol 24-C-methyltransferase (EC:2.1.1.41) |
ERG2 | C-8 sterol isomerase (EC:5.3.3.5) |
ERG3 | C-5 sterol desaturase (EC:1.3.3.-) |
ERG5 | C-22 sterol desaturase (EC:1.14.-.-) |
ERG4 | C24(28) sterol reductase (EC:1.3.1.71) |