Figure 4

Results of proteomic contrast of cells transformed with high copy mutant plasmids and nontransformed cells. Downregulated (a) and up regulated (b) proteins are shown. In each category, a pie chart shown in inset breaks down the proteins into functional clusters. Functional grouping key: metabolic enzyme (solid black), translation-related (light gray), stress (medium gray/dots), and lipid-related (diagonal stripes). * denotes an isozyme or compensating enzyme activity exists.