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Table 2 Comparison of the performances of the different E. coli strains for arginine production by fermentation

From: Metabolic engineering of Escherichia coli for enhanced arginine biosynthesis

E. coli strain

 

Yields

    

μ (1/h)

Y X/S (g dcw/g glc)

Y P/S (g arg/g glc)

Y P/X (g arg/g dcw)

Q P (g/L/h)

Arginine (g/L)

Acetic acid (g/L)

Ac/Arg (mol ac/mol arg)

SJB001

0.14 ± 0.02

0.26 ± 0.02

0.03 ± 0.00

0.10 ± 0.00

0.08 ± 0.00

1.94 ± 0.12

5.57 ± 0.11

8.5 ± 0.36

SJB003

0.14 ± 0.00

0.27 ± 0.01

0.04 ± 0.01

0.15 ± 0.03

0.14 ± 0.02

3.03 ± 0.59

6.12 ± 1.14

6.43 ± 2.36

SJB004

0.13 ± 0.02

0.27 ± 0.01

0.03 ± 0.00

0.11 ± 0.00

0.09 ± 0.00

2.04 ± 0.00

6.15 ± 0.24

8.90 ± 0.36

SJB015

0.04 ± 0.00

0.11 ± 0.00

0.07 ± 0.00

0.50 ± 0.02

0.08 ± 0.00

4.11 ± 0.49

15.85 ± 1.60

11.37 ± 0.22

SJB006

0.17 ± 0.01

0.35 ± 0.01

0.03 ± 0.00

0.09 ± 0.00

0.11 ± 0.00

2.03 ± 0.05

6.24 ± 0.45

9.07 ± 0.42

SJB007

0.16 ± 0.02

0.36 ± 0.01

0.04 ± 0.00

0.11 ± 0.00

0.14 ± 0.00

2.74 ± 0.21

5.31 ± 1.73

5.90 ± 2.31

SJB009

0.04 ± 0.00

0.12 ± 0.01

0.17 ± 0.01

1.18 ± 0.01

0.24 ± 0.01

11.64 ± 0.75

14.56 ± 0.93

3.72 ± 0.48

SJB010

0.09 ± 0.00

0.25 ± 0.01

0.11 ± 0.00

0.44 ± 0.02

0.29 ± 0.01

7.95 ± 0.04

3.14 ± 0.87

1.17 ± 0.33

  1. Aerobic batch fermentations were performed in 1 L bioreactors at 32°C and pH 7; the initial glucose concentration was 70 g/L. μ, growth rate; YX/S, biomass yield vs. glucose; YP/S, product yield vs. glucose; YP/X, product yield vs. cell mass; QP, volumetric productivity. Results are given as means ± standard deviations.