Figure 5

Fed-batch cultivation for GABA production with different pH conditions. (A) Time profiles of cell growth and glucose concentration. Circle, triangle, and square symbols indicate pH 5, pH 6 and pH 7, respectively. Open and closed symbols indicate the glucose concentration and cell density, respectively. (B) Time profiles of L-glutamate and GABA concentrations. Circle, triangle, and square symbols indicate pH 5, pH 6 and pH 7, respectively. Open and closed symbols indicate the GABA and glutamate concentrations, respectively. The first time points for glucose feeding were indicated by gray-solid (pH 5), black-dashed (pH 6) and black-solid (pH 7) arrows.