From: Development of bio-based fine chemical production through synthetic bioengineering
Compounds | Strains | Genetic engineering a | Substrates | Yield (g/L) | Reference |
---|---|---|---|---|---|
Vanillin | S. pombe | He: 3-dehydroshikiminate dehydratase (3DSD), Aryl carboxylic acid reductase (ACAR, Nocardia sp.), o-methyltransferase (OMT), UDP-glycosyltransferase (UGT, A. thaliana) | Glucose | 0.065 | Hansen et al., 2009 [51] |
 | S. cervisiae | He: 3DSD, ACAR, OMT, UGT |  |  |  |
Vanillin β-D-glucoside | S. cervisiae | He: 3DSD, ACAR, phosphopantetheine transferase (PPTase), hsOMT (Homo sapiens), UGT | Glucose | 0.5 | Brochado et al., 2010 [52] |
De: pdc1gdh1↑GDH2 | |||||
 | S. cervisiae | He: ACAR, hsOMT, | Glucose | 0.38 | Brochado et al., 2013 [58] |
Oe: GDH2 | |||||
De: pdc1 gdh1 yprC | |||||
Cinnamic acid | P. putida | He: Phenylalanine ammmonia lyase (PAL, Rhodosporidium toruloides) | Glucose | 0.74 | Nijkamp et al., 2005 [62] |
Glycerol | 0.8 | ||||
 | S. lividans | He: PAL (Streptomyces maritimus) | Glucose | 0.12 | Noda et al., 2011 [60] |
Starch | 0.46 | ||||
Xylose | 0.3 | ||||
Xylan | 0.13 | ||||
p-hydroxycinnamic acid (p-coumaric acid) | S. cervisiae | He: PAL/TAL (Rhodotorula glutinis), plant Cytochrome P450 (Cyt P450), Cyt reductase | Glucose | Â | Vannelli et al., 2007 [62] |
 | E. coli | He: PAL/TAL (R. glutinis) |  | 0.10 |  |
 | S. lividans | He: Tyrosine ammmonia lyase (TAL, Rhodobacter sphaeroides) | Glucose | 0.75 | Kawai et al., 2013 [63] |
Cellobiose | 0.74 | ||||
 |  | He: TAL (R. sphaeroides), Endoglucanase (Thermobifida fusca) | PASC | 0.5 |  |
 | P. putida | He: PAL (Rhodosporidium toruloides) | Glucose | 1.7 | Nijkamp et al., 2007 [64] |
Mu: phenylalanine bradytrophic | |||||
De: fcs | |||||
 | E. coli | He: TAL (Saccharothrix espanaensis) | Glucose | 0.97 | Kang et al., 2012 [65] |
Mu: tyrA fbr aroG fbr | |||||
De: tyrR | |||||
Caffeic acid | E. coli | He: Cyt P450 (Rhodopseudomonas palustris) | p-hydroxycinnamic acid | 2.8 | Furuya et al., 2012 [66] |
 |  | He, Mu: Cyt P450 | Cinnamic acid |  |  |
 | He: TAL, 4-coumarate hydroxylase (Sam5, S. espanaensis), | Glucose | 0.15 | Kang et al., 2012 [65] | |
Mu: tyrA fbr aroG fbr | |||||
De: tyrR | |||||
 |  | He: TAL (R. glutinis codon-optimized), 4-coumarate: CoA ligase (4CL), 4-coumarate 3-hydroxylase (Coum3H, S. espanaensis) | Glucose | 0.10 | Zhang et al., 2013 [67] |
Xylose | 0.07 | ||||
Mu: tyrA fbr aroG fbr | |||||
De: tyrR pheA |