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Table 4 Microbial fermentation of aromatic compounds

From: Development of bio-based fine chemical production through synthetic bioengineering

Compounds

Strains

Genetic engineering a

Substrates

Yield (g/L)

Reference

Vanillin

S. pombe

He: 3-dehydroshikiminate dehydratase (3DSD), Aryl carboxylic acid reductase (ACAR, Nocardia sp.), o-methyltransferase (OMT), UDP-glycosyltransferase (UGT, A. thaliana)

Glucose

0.065

Hansen et al., 2009 [51]

 

S. cervisiae

He: 3DSD, ACAR, OMT, UGT

   

Vanillin β-D-glucoside

S. cervisiae

He: 3DSD, ACAR, phosphopantetheine transferase (PPTase), hsOMT (Homo sapiens), UGT

Glucose

0.5

Brochado et al., 2010 [52]

De: pdc1gdh1↑GDH2

 

S. cervisiae

He: ACAR, hsOMT,

Glucose

0.38

Brochado et al., 2013 [58]

Oe: GDH2

De: pdc1 gdh1 yprC

Cinnamic acid

P. putida

He: Phenylalanine ammmonia lyase (PAL, Rhodosporidium toruloides)

Glucose

0.74

Nijkamp et al., 2005 [62]

Glycerol

0.8

 

S. lividans

He: PAL (Streptomyces maritimus)

Glucose

0.12

Noda et al., 2011 [60]

Starch

0.46

Xylose

0.3

Xylan

0.13

p-hydroxycinnamic acid (p-coumaric acid)

S. cervisiae

He: PAL/TAL (Rhodotorula glutinis), plant Cytochrome P450 (Cyt P450), Cyt reductase

Glucose

 

Vannelli et al., 2007 [62]

 

E. coli

He: PAL/TAL (R. glutinis)

 

0.10

 
 

S. lividans

He: Tyrosine ammmonia lyase (TAL, Rhodobacter sphaeroides)

Glucose

0.75

Kawai et al., 2013 [63]

Cellobiose

0.74

  

He: TAL (R. sphaeroides), Endoglucanase (Thermobifida fusca)

PASC

0.5

 
 

P. putida

He: PAL (Rhodosporidium toruloides)

Glucose

1.7

Nijkamp et al., 2007 [64]

Mu: phenylalanine bradytrophic

De: fcs

 

E. coli

He: TAL (Saccharothrix espanaensis)

Glucose

0.97

Kang et al., 2012 [65]

Mu: tyrA fbr aroG fbr

De: tyrR

Caffeic acid

E. coli

He: Cyt P450 (Rhodopseudomonas palustris)

p-hydroxycinnamic acid

2.8

Furuya et al., 2012 [66]

  

He, Mu: Cyt P450

Cinnamic acid

  
 

He: TAL, 4-coumarate hydroxylase (Sam5, S. espanaensis),

Glucose

0.15

Kang et al., 2012 [65]

Mu: tyrA fbr aroG fbr

De: tyrR

  

He: TAL (R. glutinis codon-optimized), 4-coumarate: CoA ligase (4CL), 4-coumarate 3-hydroxylase (Coum3H, S. espanaensis)

Glucose

0.10

Zhang et al., 2013 [67]

Xylose

0.07

Mu: tyrA fbr aroG fbr

De: tyrR pheA

  1. aTypes of genetic engineering: He, Heterologous expression; Oe, Overexpression of self-cloning gene(s); Mu, Mutation; De, Deletion.