From: Metabolic engineering of microorganisms for the production of L-arginine and its derivatives
Product | Year | Strain (vector if any) | Remark | Titer (g/liter) | Reference |
---|---|---|---|---|---|
ARG | 1971 | AHr-5 | AHX resistant B. subtilis; test tube culture | 4.5 | [18] |
1973 | AJ 3351 | B. ketoglutamicum ATCC 15587 mutant; SGR, | 2.1 | [75] | |
AJ 3352 | A. paraffineus ATCC 19065 mutant; TAR, | 1.2 | |||
AJ 3353 | M. ammoniaphilum ATCC 15354 mutant; TAR, | 2.9 | |||
No. 348 | C. lilium NRRL B-2243 mutant; TAR | 1.8 | |||
No. 352 | B. flavum ATCC 14067 mutant; guanine auxotroph; TAR | 34.8 | |||
1977 | AAr-9 | B. subtilis OUT 8103 mutant; 6AUR | 28.0 | [74] | |
1981 | KY7690 | B. subtilis ATCC 15244 mutant; AHXR, 5HURR, TRAR, 6FTPR, 6AUR, 2TUR; 5 liter bioreactor | 14.0 | [73] | |
S. marcescens | IFO 3046 mutant; AHXR, NIMR; test tube culture | 0.6 | |||
M. ammoniaphilum | ATCC 15354 mutant; AHXR; test tube culture | 0.5 | |||
M. sodonensis | ATCC 11880 mutant; AHXR; test tube culture | 4.0 | |||
N. corynebacteroides | ATCC 14898 mutant; CVNR; test tube culture | 2.5 | |||
N. rubra | NRRL 11094 mutant; AHXR; test tube culture | 8.0 | |||
2009 | RBid | C. glutamicum ATCC 13032, ΔargR, A26V/M31V in ArgB; 5 liter bioreactor | 52.0 | [47] | |
2009 | SYPA 5-5 | C. crenatum mutant; optimization of two-stage oxygen supply strategy; 5 liter bioreactor | 36.6 | [76] | |
2011 | SYPA 5–5 (pJC-tac-vgb) | C. crenatum mutant, vector-based overexpression of vgb from Vitreoscilla | 35.9 | [77] | |
2011 | SYPA 5–5 (pJCtac-argJ) | C. crenatum mutant, vector-based overexpression of argJ; 5 liter bioreactor | 42.4 | [34] | |
2012 | SYPA-9039 (pJC-9039) | C. crenatum SYPA5-5 harboring with vector-based overexpression of argCJBDFRGH; 5 liter bioreactor | 45.3 | [78] | |
2014 | AR6 | C. glutamicum ATCC 21831; AHXR, CVNR, ΔargR, ΔfarR, pgi (A1G), Psod::tkt, tal, zwf, opcA, pgl, ΔNCgl1221, Psod::carAB, Petfu::argGH; 5 liter bioreactor | 92.5 | [9] | |
Same as above except 1,500 liter bioreactor | 81.2 | ||||
ORN | 1996 | BK533 | B. ketoglutamicum ATCC 21092 derived mutant; UV and NTG treatment; 2 liter bioreactor | 5.7 | [79] |
2008 | SJ8074 (pEK-CJBD) | C. glutamicum ATCC 13032 ΔargF, ΔargR, ΔproB, vector-based overexpression of argCJBD | 0.179 | [80] | |
2010 | SJ8074 (pEK-Ptrc::1469) | C. glutamicum ATCC 13032 ΔargF, ΔargR, ΔproB, vector-based overexpression of NCgl1469 | 0.320 | [54] | |
2010 | C. glutamicum | ATCC 13032; proline supplement | 3.295 | [62] | |
2011 | ORN1 (pVWEx1-araBAD) | C. glutamicum ATCC 13032 ΔargF, ΔargR, vector-based overexpression of araBAD; optimal ARG supplement, arabinose supplement | 25.77 | [81] | |
2012 | C. glutamicum | ATCC 13032 ΔargF, ΔproB, Δkgd | 4.78 | [82] | |
2012 | SJC8399 | C. glutamicum ATCC ΔargF, ΔargR, ΔNcgl2399, ΔNcgl2905 | 13.16 | [83] | |
2013 | ΔAPRE::rocG | C. glutamicum ATCC 13032 ΔargF, ΔproB, ΔargR, ΔspeE::P tac-M -rocG | 14.84 | [84] | |
2013 | ΔAPE6937R42 | C. glutamicum ATCC 13032 ΔargF, ΔproB, ΔspeE, ΔargR; 70 passages of adaptive evolution | 24.1 | [85] | |
2014 | YW6 (pSY233) | C. glutamicum ATCC 13032 ΔproB, ΔargF, ΔargR, pgiGTG, zwfATG, Ptkt::Psod, vector-based overexpression of argCJBD from C. glutamicum ATCC 21831; 5 liter bioreactor | 51.5 | [86] | |
Putrescine | 2009 | XQ52 (p15SpeC) | E. coli W3110 ΔlacI, ΔspeE, ΔspeG, ΔargI, ΔpuuPA, PargECBH::Ptrc, PspeF-potE::Ptrc, PargD::Ptrc, PspeC::Ptrc, ΔrpoS, vector-based overexpression of speC; 5 liter bioreactor | 24.2 | [28] |
2010 | ORN1 (pVWEx1-speC) | C. glutamicum ATCC 13032 ΔargF, ΔargR, vector-based overexpression of speC from E. coli MG1655; ARG supplement, | 6.0 | [50] | |
2012 | ORN1 (pVWEx1-speC-5’ 21 -argF) | C. glutamicum ATCC 13032 ΔargF, ΔargR, vector-based overexpression of speC from E. coli MG1655; ARG auxotrophy rescue by fine-tuned argF expression via plasmid-addiction system | 19.0 | [51] | |
2013 | ORN1 (pVWEx1-speC-5’ 21 -argF) | C. glutamicum ATCC 13032 ΔargF, ΔargR, vector-based overexpression of speC from E. coli MG1655; glycerol and glucose as carbon source; ARG supplement | 0.855 | [87] | |
Cyanophycin | 2001 | C. glutamicum (pEK0::cphA) | ATCC 13032, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308 | 3.6 | [88] |
H16-PHB−4 (pBBR1::cphA) | R. eutropha DSM 541 (DSM 428 derivative), PHA synthesis defect, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308 | 8.7 | |||
E. coli (pSK::cphA) | TOP 10, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308 | 26.0 | |||
P. putida (pBBR1::cphA) | KT2440, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308 | 11.0 | |||
2002 | E. coli (pMa/c5-914::cphA) | DH1 strain, vector-based overexpression of cphA from Synechocystis sp. PCC6803; 30 liter bioreactor | 24.0 | [89] | |
Same as above except 500 liter bioreactor | 21.0 | ||||
2004 | E. coli (pSK::cphA1 7120) | TOP 10, vector-based overexpression of cphA1 from Anabaena sp. strain PCC7120 | 21.0 | [90] | |
GPp104 (pBBR1MCS-2::cphA1 7120) | P. putida KT2440 mutant, vector-based overexpression of cphA1 from Anabaena sp. strain PCC7120 | 24.0 | |||
H16-PHB−4 (pBBR1MCS-2::cphA1 7120) | R. eutropha DSM 541 (DSM 428 derivative), PHA synthesis defect, vector-based overexpression of cphA1 from Anabaena sp. strain PCC7120 | 22.0 | |||
2005 | A. calcoaceticus | ATCC 33305, flask cultivation; ARG supplement | 46.0 | [91] | |
2006 | R. eutropha (pBBR1MCS-2::cphA/eda) | DSM 541 derivative, H16-PHB−4 Δeda, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308; eda-dependent plasmid-addiction system; flask cultivation | 40.0 | [92] | |
Same as above except 30 liter bioreactor | 35.8 | ||||
Same as above except 500 liter bioreactor | 32.0 | ||||
2011 | E. coli (pCOLADuet-1::cphAC595S::dapL Ss) | HMS174(DE3) ΔdapE, plasmid-addiction system using dapL from Synechocystis sp. Strain PCC6308, C595S mutant cphA from Synechocystis sp. Strain PCC6308; flask cultivation | 42.0 | [93] | |
Same as above except 25 liter bioreactor | 14.1 | ||||
Same as above except 400 liter bioreactor | 18.0 | ||||
2012 | R. eutropha (pBBR1MCS-2::cphA 6308 /eda H16) | DSM 428 mutant, H16-PHB−4 Δeda, vector-based overexpression of cphA from Synechocystis sp. Strain PCC6308, eda-dependent plasmid-addiction system; 30 liter bioreactor | 47.5 | [94] |