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Figure 1 | Microbial Cell Factories

Figure 1

From: Metabolic engineering of microorganisms for the production of L-arginine and its derivatives

Figure 1

Representative ARG biosynthesis routes in prokaryotes. (A) The linear pathway, (B) the recycling pathway and (C) the newly discovered pathway for the ARG biosynthesis are shown. Dashed line indicates feedback inhibition by ARG on the first (NAGS) (A) and second (NAKG) (B) committed steps in the pathways. Blue arrows indicate argE used in the linear pathway (A). Orange arrows indicate argJ used in the recycling pathway (B). Green arrow indicates argF’ used in the newly found pathway (C). ARG catabolic pathways are also shown. Ac-GLU, N-acetylglutamate; Ac-GLU-P, N-acetylglutamyl-5-phosphate; Ac-GLU-SA, N-acetylglutmate-5-semialdehyde; ARG-Suc, L-argininosuccinate; GLU-SA, L-glutamate-5-semialdehyde; P5C, 1-pyrroline-5-carboxylate. The asterisk indicates putative NAGS that has not been characterized in many organisms.

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