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Figure 1 | Microbial Cell Factories

Figure 1

From: An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines

Figure 1

Strategy for Hbp-mediated secretion and display of heterologous antigens. Schematic representation of the secretion and display strategy based on the Hbp passenger and β-domain crystal structures [25],[27]. Heterologous antigens x, y, and z are fused to the Hbp passenger domain, individually or simultaneously, by (partially) replacing any of the side domains d1 (red), d2 (green), d3 (yellow), d4 (magenta) or d5 (orange). Scissors indicate a cleavage site between the passenger and β-domain, which was left intact (+) for secretion purposes and disrupted (β) for surface display. The image was created using MacPyMol.

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