Figure 1

Metabolic network of carbon source metabolism by Clostridium acetobutylicum reconstructed from the genome annotation, KEGG, and BioCyc. Numbers adjacent to arrows represent the following enzyme activities and their corresponding genes. 1) glucose PTS, CA_C0570; 2) phosphoglucose isomerase, CA_C2680; 3) phosphofructokinase, CA_C0517; 4) fructose-bis-P aldolase, CA_C0827, CA_P0064; 5) triosephosphate isomerase, CA_C0711; 6) glyceradehyde-3-P dehydrogenase, CA_C0709; 7) phosphoglycerate kinase, CA_C0710; 8) phosphoglycerate mutase, CA_C0712, CA_C2741, CA_C3021; 9) enolase, CA_C0713; 10) pyruvate kinase, CA_C0518, CA_C1036; 11) pyruvate ferredoxin oxidoreductase, CA_C2229, CA_C2499; 12) hydrogenase, CA_C0028; 13) NAD⁺/ferredoxin oxidoreductase, CA_C?; 14) thiolase, CA_C2873, CA_P0078; 15) phosphotransacetylase, CA_C1742; 16) acetate kinase, CA_C1743; 17) hydroxybutyryl-CoA dehydrogenase, CA_C2009, CA_C2708; 18) crotonase, CA_C2012, CA_C2016, CA_C2712; 19) butyryl-CoA dehydrogenase, CA_C2711; 20) phosphotransbutyrylase, CA_C3076; 21) butyrate kinase, CA_C1660, CA_C3075; 22) galacturonate symporter, CA_C0694; 23) galacturonate isomerase, CA_C0692 24) altronate oxidoreductase, CA_C0695; 25) altronate dehydratase, CA_C0696; 26) 2-keto-3-deoxygluconokinase, CA_C0395; 27) 2-keto-3-deoxygluconate 6-phosphate aldolase, CA_C0394, CA_C2973; 28) gluconate symporter, CA_C3605; 29) gluconate dehydratase, CA_C3604.