Table 1 Relevant E. coli strains engineered for the overproduction of compounds derived from the aromatic biosynthetic pathway

SP1.1pts/ pSC6.090B (RB791 derivative)

ΔptsHIcrr ΔaroK ΔaroL serA::aroB / (plasmid) aroF ^fbr tktA, P_tac aroE serA, P_tac glf ^c glk ^c

SHK (84, 0.33^b). 100L fed-batch reactors with glucose, AAA and 150g/L of yeast extract

AR36 (JM101 derivative)

ΔptsHIcrr ΔaroK ΔaroL ΔlacI ΔpykF / (plasmid) P_trc aroB tktA aroG ^fbr aroE aroD zwf

SHK (43, 0.42^b). 10L batch reactors with 1000g/L of glucose and 300g/L of yeast extract

SA116 (BW25113 derivative)

ΔaroK ΔaroL P_pps::P_lacQ1, P_csrB::P_lacQ1 / (chromosome) aroG ^fbr tktA aroB aroE, P_T5 ppsA csrB, 5P_tac tktA nadK

SHK (3, 0.33^b). Medium supplemented with 100g/L of glucose, 10g/L of peptone and 10g/L of proline

W14/pR15BABKG (W3110 derivative)

Δcrr ΔtyrA / (plasmid) P_R aroG15 tyrB, P_L pheA ^fbr ydiB aroK yddG

L-PHE (47, 0.25^d). 150L fed-batch reactors with glucose and 10g/L of tyrosine

FUS4.11/pF81_kan (W3110 derivative)

ΔpheA ΔtyrA ΔaroF ΔlacIZYA ΔpykA ΔpykF / (chromosome) P_tac aroF aroB aroL, (plasmid) P_tac pheA ^fbr aroF aroB aroL

L-PHE (13, 0.15^d). 150L multi-phase fed-batch reactors with glycerol and lactic acid

BL21 (DE3)

(plasmid) containing the phenylalanine dehydrogenase gene of Acinetobacter lwoffii

L-PHE (5, 0.58^d) 20L batch reactors with 100g/L of glycerol

MG1655 derivative

(plasmid) P_lac-UV5 aroE aroD aroB ^op, P_L-tetO1 aroG ^fbr ppsA tktA, (plasmid) P_lac-UV5 tyrB tyrA ^fbr aroC, P_trc aroA aroL

L-TYR (2, 0.44^d). Shake flask cultures with 50g/L of glucose

rpoA 14^R (K-12 derivative)

ΔpheA ΔtyrR / (chromosome) P_L tyrA ^fbr aroG ^fbr, point mutations in hisH and purF, (plasmid) rpoA

L-TYR (14, 0.12^d) 20L fed-batch reactors with glucose

MG1655 derivative

ΔpheA ΔpheL / (chromosome) P_trc tyrA

L-TYR (55, 0.30^d). 2000L fed-batch reactors with glucose

FB-04/pSV03 (W3110 derivative)

ΔtrpR ΔtnaA ΔpheA ΔtyrA / (plasmid) aroF ^fbr trpE ^fbrD

L-TRP (13, 0.10^d). 30L fed-batch reactors with glucose, 20g/L of L-PHE and 30g/L of L-TYR

GPT1017 (W3110 derivative)

ΔtrpR ΔtnaA ΔptsG ΔaroP ΔtnaB Δmtr / (chromosome) swapping of tryptophan attenuator and trp promoter by 5CP_tacs, (plasmid) aroG ^fbr trpE ^fbr tktA

L-TRP (16). 50L fed-batch reactors with glucose and 10g/L of yeast extract

TRTH0709/pMEL03 (MG1655 derivative)

ΔtrpR ΔtnaA Δpta Δmtr / (plasmid) aroG ^fbr trpE ^fbrDCBA serA, (plasmid) tktA ppsA yddG

L-TRP (49). 300L fed-batch reactors with glucose and 10g/L of yeast extract

Vio-4 (MG1655 derivative)

ΔtrpR ΔtnaA ΔsdaA Δlac ΔtrpL Δgal Δxyl Δfuc / (chromosome) P_tac aroF aroB aroL tktA serA ^fbr vioD ^f , trpE ^fbr, (plasmid) vioABCE ^g

Violacein (0.7). 0.70L fed-batch reactors with arabinose, 120g/L of tryptone and 240g/L of yeast extract

BKD5 (BW25113 derivative)

ΔptsG ΔtyrR ΔpykA ΔpykF ΔpheA / (plasmid) P_lacUV5 aroG ^fbr tyrA ^fbr aroE, P_trc ppsA tktA glk, (plasmid) P_lacUV5 T7 RNA polymerase, (plasmid) hpaBC d-ldh ^h

Salvianic acid A (7, 0.47^b). 0.50L fed-batch flasks with glucose and 10g/L of yeast extract

QH23 (ATCC 31884 derivative)

ΔpheLA ΔtyrA / (plasmid) P_{L lacO1} tyrA ^fbr ppsA tktA aroG ^fbr, (plasmid) P_{L lacO1} tal ^{i, op} hpaBC

Caffeic acid (0.8). Shake flask cultures with 2.50g/L of glucose, 100g/L of glycerol and phenylalanine

pAD-AG/ΔtyrR (BL21 (DE3) derivative)

ΔtyrR / (plasmid) aroG ^fbr tyrA ^fbr, (plasmid) tal ^j

4-coumaric acid (1). Shake flask cultures with 150g/L of glucose

VH33 ΔtyrR_DOPA (W3110 derivative)

ΔptsHIcrr / (chromosome) P_trc galP, (plasmid) tktA P_lacUV5 aroG ^fbr, (plasmid) P_trc tyrC ^c pheA

L-DOPA (1.5, 0.05^d). 10L batch reactors with LB and 500g/L glucose

W3110 trpD9923/pS0 + pY + pAvnD

(plasmid) P_L-tetO1 ydiB aroD aroB aroG ^fbr ppsA tktA, (plasmid) P_lacUV5 tyrB tyrA ^fbr aroC aroA aroL, (plasmid) P_lacUV5 HCBT ^k 4CL1 ^l tal ⁱ

Avenanthramide D (27^e). Shake flask cultures with 100g/L of glucose