Figure 1
From: Rational and combinatorial approaches to engineering styrene production by Saccharomyces cerevisiae
Styrene biosynthesis by engineered S. cerevisiae. Dashed arrows signify multiple steps are involved but not illustrated. Black arrows represent enzymes steps native to S. cerevisiae whereas gray arrows are heterologous; dotted arrows represent multiple enzymatic steps; feedback repression is shown using thin dotted lines with flat heads whereas transcriptional activation is shown using thin dotted lines with a round head and ‘+’; disruption of a gene or regulatory mechanism is signified by ‘X’. Abbreviations: phosphoenolpyruvate (PEP), erythrose-4-phosphate (E-4P), 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP), hydroxyphenylpyruvate (HPP), 2-phenylacetaldehyde (PAA).