Figure 4
From: Mucosal vaccine delivery by non-recombinant spores of Bacillus subtilis
Combined recombinant and non-recombinant spore-surface display. A) The diterpen paclitaxel, used as an example of non-proteinaceous molecule adsorbed to the spore. B) Spore displaying streptavidin by the recombinant approach and paclitaxel by the non-recombinant one. By streptavidin-biotin interaction the spore binds to a biotinylated anti-EGFR primary antibody targeting the spore to the EGFR-exposing cell [43].