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Table 3 In silico prediction of growth in glycerol/methanol mixtures

From: Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement

 

Dilution rate, D

 

D = 0.16

D = 0.16

D = 0.05

D = 0.05

 

Expa

Pred

Expa

Pred

Expa

Pred

Expa

Pred

Cell growth

0.16

0.18

0.16

0.19

0.05

0.05

0.05

0.05

Glycerol uptake b

2.75

2.23

1.09

0.57

Methanol uptake b

-

2.73

-

2.33

CO 2 evolution

2.35

2.40

3.60

3.22

1.56

1.72

2.21

2.37

O 2 uptake

3.62

3.56

7.20

5.47

2.16

2.20

4.85

3.76

Respiratory quotient

0.65

0.68

0.50

0.59

0.72

0.78

0.46

0.63

P/O ratio

-

1.48

-

1.48

-

1.47

-

1.49

  1. In the chemostat culture, growth rate is equivalent to dilution rate. Units of measurements are given as follows: growth/dilution rate, 1/hr; carbon source uptake or gaseous exchange rates, mmol/gDCW-hr; Respiratory quotient, mol CO2/mol O2; P/O ratio, mol ATP/mol O.
  2. a Data from [38].
  3. b Carbon source uptake rates are model input parameters which are not predicted.
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