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Table 2 Parameters values for modelling fed-batch reactor carried out with the parental S. cerevisiae BY4741 [PIR4-IL1β] and the mutant S. cerevisiae BY4741 Δyca1 [PIR4-IL1β].

From: Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

Parameter

Parental strain

Δyca1 mutant

Determination

t 1

7 h

7 h

Experimental

t 2

19 h

22 h

Experimental

μ 1

0.18 h-1

0.16 h-1

Experimental

k d

0.026 h-1

0.005 h-1

Experimental

δ

0.126 h-1

0.131 h-1

by fitting

λ

0.139 h-1

0.146 h-1

by fitting

α

0.004 h-3

0.079 h-3

by fitting

β

0.025 h-2

0.006 h-2

by fitting

γ

0.039 h-1

0.081 h-1

by fitting

0.313 h-1

0.307 h-1

Experimental

0.007 h-1

0.013 h-1

by fitting

1.03 h-1

1.76 h-1

by fitting

Y P/X

0.0001

0.0001

Experimental