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Table 1 Modeling of fed-batch reactor for both the parental S. cerevisiae BY4741 [PIR4-IL1β] and the mutant S. cerevisiae BY4741 Δyca1 [PIR4-IL1β]: balance equations and kinetic expressions for the variables of interest.

From: Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1β in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy

Variable

Balance Equation

Kinetic Expression

Biomass

μ1 = constant

0 ≤ t <t1

  

μ2 = μ1 exp [-δ (t-t1)]

tt1

  

kd = constant

t

Glucose

= constant

0 ≤ t <t1

  

= exp [-λ (t-t1)]

tt1

  

= constant 0

t <t1

  

= a(t-t1)2 + β (t-t1) + γ

t1t <t2

  

qm3 = constant

t ≥ t2

Product

(IL-1 β )

YP/X= constant

t