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Table 2 Effect of L-lysine and L-glutamate on nikkomycin Z production in sanPDM in the presence of 2 g/L uracil

From: Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

Culture conditions

Nikkomycin Z production

(mg/L)

Biomass

(g/L)

Control

785 ± 10

9.9 ± 1.9

L-lysine

  

   0.5%

780 ± 16

10.2 ± 2.1

   1%

700 ± 40

9.2 ± 1.3

   2%

500 ± 9

5.3 ± 1.9

L-glutamate

  

   0.5%

770 ± 30

9.7 ± 1.7

   1%

720 ± 12

9.5 ± 2.1

   2%

400 ± 23

4.8 ± 1.6

L-lysine+L-glutamate

  

   0.5%+0.5%

750 ± 30

9.6 ± 1.5

   1%+1%

740 ± 24

9.8 ± 2.0