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Table 2 Effect of L-lysine and L-glutamate on nikkomycin Z production in sanPDM in the presence of 2 g/L uracil

From: Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes

Culture conditions Nikkomycin Z production (mg/L) Biomass (g/L)
Control 785 ± 10 9.9 ± 1.9
L-lysine   
   0.5% 780 ± 16 10.2 ± 2.1
   1% 700 ± 40 9.2 ± 1.3
   2% 500 ± 9 5.3 ± 1.9
L-glutamate   
   0.5% 770 ± 30 9.7 ± 1.7
   1% 720 ± 12 9.5 ± 2.1
   2% 400 ± 23 4.8 ± 1.6
L-lysine+L-glutamate   
   0.5%+0.5% 750 ± 30 9.6 ± 1.5
   1%+1% 740 ± 24 9.8 ± 2.0