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Figure 5 | Microbial Cell Factories

Figure 5

From: An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli

Figure 5

Simplified model for the alterations in the metabolic network of E. coli after pta deletion. Lactate is produced as a result of the knock-out of the pta gene and it is used to produce ATP by the combined action of lactate dehydrogenases, nLDH and iDLDH. Moreover, pyruvate accumulation would activate the pdh operon. The enzymes involved are shown in the figure [ACK (ackA), acetate kinase; PTA (pta), phosphotransacetylase, PDH (aceEF;lpd) pyruvate dehydrogenase (Ecocyc-Metacyc [45]).

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