| Bioreactor Comparison 1 | Bioreactor Comparison 2 | ||
---|---|---|---|---|
Parameter | CultiBag | HTBR | CultiBag | HTBR |
culture volume | 2 L | 35 ml | 3.5 L | 35 ml |
peak vcd (× 106 cells/ml) | 1.28 | 1.18 ± 0.24 | 0.76 | 0.70 ± 0.18 |
final IVCD (× 106 cells/ml-h) | 59.70 | 50.63 ± 9.89 | 38.39 | 23.85 ± 8.05 |
peak mAb concentration (mg/l) | 92.92 | 92.16 ± 7.08 | 42.41 | 26.65 ± 4.51 |
average growth rate (1/h) | 0.026 | 0.029 ± 0.007 | 0.036 | 0.022 ± 0.005 |
average mAb productivity (pg/cell-d) | 37.35 | 44.87 ± 12.08 | 32 | 28.64 ± 5.70 |