Skip to main content

Advertisement

Table 2 Estimated optimum free fluxes (mmol/100 mmol Glucose) and the associated 90% confidence interval.

From: OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis

   Wild-type Mutant
Flux parameter   Optimum 90% CI Optimum 90% CI
Glucose-6P dehydrogenase A 46.8 [46.3, 47.3] 56.2 [55.9, 56.5]
  B 46.7 [46.3, 47.1] 56.3 [56.1, 56.5]
  C   [46.2, 47.3]   [56.0, 56.6]
Pyruvate carboxylase A 71.5 [67.6, 75.7] 62.6 [60.0, 64.8]
  B 74.9 [70.9, 79.3] 63.6 [61.8, 65.6]
  C   [70.4, 79.5]   [61.2, 65.7]
Glucose-6P isomerase (rev) A 1.3 [1.2, 1.3] 2.4 [2.3, 2.4]
  B 1.27 [1.26, 1.30] 2.37 [2.33, 2.39]
  C   [1.24, 1.31]   [2.32, 2.41]
Transketolase 1 (rev) A 0 [2.1, 2.5] 0 [0, 0]
  B 2.21 [2.03, 2.35] 0 [0, 0]
  C   [1.93, 2.49]   [0, 0]
Transaldolase (rev) A 2.2 [2, 2.3] 4.5 [4.3, 4.6]
  B 2.16 [2.06, 2.24] 4.50 [4.40, 4.62]
  C   [2.00, 2.33]   [4.31, 4.69]
Transketolase 2 (rev) A 1 [0.7, 1.3] 1.6 [1.4, 1.7]
  B 1.02 [0.84, 1.21] 1.50 [1.44, 1.57]
  C   [0.73, 1.41]   [1.41, 1.61]
  1. A. Original work [39]; B. Gradient-based search; C. Monte Carlo. B's and C's optimum values are derived from the best optimum solution found by OpenFLUX. The unit for fluxes and confidence intervals is mmol/100 mmol glucose.