Figure 3
Location and nature of the S. erythraea rif mutations. Alignment of deduced amino acid sequence of rifampicin resistance-determining region (RRDR) of E. coli, Mycobacterium tuberculosis, S. lividans and S. erythraea with location of: i) the rif (rpoB) mutations more frequently associated with rifampicin-resistance in E. coli and their relative phenotypes (upper part of the panel); ii) the amino acid residues (underlined in the middle part of the panel) that, when mutated, are responsible for activation of cryptic antibiotic biosynthesis in S. lividans; iii) the missenses of the S. erythraea rif1-rif6 mutants.