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Table 3 Peak areas of detected metabolites normalized to total peak area in BY4742 and the three deletion strains pat1Δ, dhh1Δ and lsm1Δ using GC/MS.

From: Metabolite profiling studies in Saccharomyces cerevisiae: an assisting tool to prioritize host targets for antiviral drug screening

  BY4742 pat1Δ dhh1Δ lsm1Δ
metabolite mean s. d. mean s. d. mean s. d. mean s. d.
glycine 4.67E-05 1.10E-05 6.07E-05 1.12E-05 5.68E-05 4.58E-06 1.97E-04 2.26E-05
alanine 1.28E-04 2.68E-05 1.34E-04 3.07E-05 2.08E-04 3.27E-05 1.06E-03 1.71E-04
pyruvic acid 1.02E-05 5.52E-06 9.87E-06 2.62E-06 6.24E-06 8.64E-07 4.59E-06 6.12E-07
lactic acid 1.65E-05 1.72E-06 1.22E-05 2.44E-06 7.95E-06 1.47E-06 7.67E-06 2.35E-06
valineE 4.73E-05 8.82E-06 6.02E-05 9.70E-06 4.91E-05 7.67E-06 1.80E-04 2.54E-05
u. m. #1 2.25E-05 5.10E-06 3.33E-05 6.92E-06 4.38E-05 1.92E-05 9.97E-06 2.39E-06
ethanolamine 8.47E-06 3.27E-06 6.76E-06 1.37E-06 1.14E-05 1.74E-06 2.11E-05 6.15E-06
glycerol 3.38E-04 5.49E-05 3.36E-04 2.36E-05 6.98E-04 6.75E-05 5.96E-04 1.01E-04
isoleucine/leucineE 5.32E-06 2.21E-06 5.08E-06 1.04E-06 7.69E-06 5.53E-07 2.22E-05 3.13E-06
succinic acid 4.71E-06 1.74E-06 2.59E-06 1.08E-07 4.65E-06 2.64E-07 1.01E-05 1.09E-06
uracil 1.55E-05 3.05E-06 1.72E-05 3.08E-06 1.70E-05 5.16E-06 1.99E-05 2.05E-06
fumaric acid 4.56E-06 1.43E-06 6.06E-06 9.78E-07 8.08E-06 3.39E-07 1.78E-05 2.32E-06
serine 2.17E-05 5.77E-06 2.10E-05 2.57E-06 3.94E-05 3.32E-06 3.45E-05 6.43E-06
threonineE 1.94E-05 4.14E-06 2.19E-05 2.94E-06 3.70E-05 3.35E-06 5.99E-05 5.37E-06
homoserineN 9.32E-06 1.60E-06 9.77E-06 1.52E-06 1.71E-05 1.15E-06 2.50E-05 2.18E-06
malic acid 3.98E-06 9.76E-07 7.88E-06 9.28E-07 1.23E-05 8.03E-07 2.30E-05 3.55E-06
u. m. #2 2.41E-06 3.99E-07 2.50E-06 4.32E-07 3.69E-06 2.40E-07 4.60E-06 4.01E-07
ErythritolN 2.13E-06 2.67E-07 1.75E-06 2.73E-07 n.d.1 n.d.1 n.d.1 n.d.1
aspartate 2.39E-05 3.44E-06 3.89E-05 3.18E-06 1.29E-04 1.20E-05 1.03E-04 1.43E-05
u. m. #6 7.99E-05 1.28E-05 7.55E-05 1.50E-05 4.56E-05 2.41E-06 4.82E-05 9.02E-06
cytosine 7.49E-06 1.03E-06 6.97E-06 1.21E-06 5.64E-06 1.90E-06 5.94E-06 1.05E-06
α-ketoglutaric acid 3.89E-07 1.84E-07 6.66E-07 9.73E-08 4.56E-07 8.42E-08 n.d.1 n.d.1
glutamate 6.97E-05 1.84E-05 1.45E-04 1.84E-05 1.33E-04 2.12E-05 8.20E-05 1.03E-05
phenylalanineE 2.56E-06 6.33E-07 3.94E-06 4.11E-07 4.88E-06 7.75E-07 3.28E-06 4.78E-07
ribose 1.50E-06 4.90E-07 8.37E-07 1.52E-07 4.72E-07 7.98E-08 5.02E-07 1.66E-07
asparagine 1.79E-06 6.49E-07 2.34E-06 3.99E-07 3.91E-06 1.09E-06 2.37E-06 7.65E-07
2-aminoadipic acid 4.03E-06 1.22E-06 2.32E-06 3.72E-07 8.49E-07 1.57E-07 4.12E-06 4.93E-07
orotic acid 6.56E-05 2.11E-05 3.38E-05 2.74E-06 1.55E-05 2.70E-06 7.66E-05 1.05E-05
glycerol-1-phosphate 5.65E-07 1.05E-07 6.80E-07 4.76E-08 5.17E-07 1.10E-07 n.d.1 n.d.1
glutamine 1.86E-06 5.48E-07 4.54E-06 3.26E-06 1.46E-05 4.06E-06 4.19E-06 4.66E-06
N-acetyl-glutamic acid 5.62E-07 1.34E-07 1.63E-06 3.29E-07 5.72E-07 9.51E-08 n.d.1 n.d.1
u. m. #3 1.06E-05 7.65E-06 8.19E-06 1.98E-06 1.88E-06 1.75E-07 1.31E-05 1.94E-06
citric acid 9.43E-06 1.82E-06 1.47E-05 1.51E-06 4.79E-04 7.40E-05 1.28E-05 3.12E-06
ornithine 3.69E-06 1.17E-06 1.17E-05 1.40E-06 1.40E-05 2.94E-06 1.69E-06 3.42E-07
arginine 4.17E-06 1.10E-06 1.19E-05 1.88E-06 6.33E-06 1.33E-06 8.16E-07 4.37E-07
adenine 3.78E-06 8.22E-07 3.84E-06 9.41E-07 3.86E-06 1.24E-06 4.82E-06 7.76E-07
lysineE 1.52E-04 4.67E-05 2.16E-04 1.11E-05 4.15E-04 3.30E-05 4.44E-04 5.42E-05
histidinEe 1.36E-05 1.63E-06 1.93E-05 8.38E-06 2.83E-05 3.25E-06 1.23E-05 8.86E-07
mannitolN 4.96E-07 7.11E-08 1.03E-06 1.34E-07 6.30E-07 9.23E-08 9.67E-07 1.55E-07
tyrosineE 8.22E-06 3.02E-06 2.14E-05 1.96E-06 1.93E-05 1.76E-06 1.72E-05 1.35E-06
u. m. #4 1.74E-06 3.53E-07 8.75E-07 1.18E-07 9.58E-07 1.96E-08 1.15E-06 2.03E-07
inositol 4.81E-05 9.72E-06 4.23E-05 3.34E-06 3.28E-05 1.83E-06 3.41E-05 3.38E-06
xylulose-5-phosphate 3.15E-06 1.36E-06 1.12E-06 1.55E-07 1.22E-06 2.81E-07 7.68E-07 6.53E-08
glucose-6-phosphate 6.96E-06 1.59E-06 5.92E-06 1.56E-06 2.11E-06 4.92E-07 1.54E-06 1.15E-06
u. m. #7 3.44E-06 5.64E-07 1.70E-06 6.00E-07 3.39E-06 1.12E-06 4.58E-06 5.05E-07
u. m. #5 2.56E-06 3.60E-07 2.73E-06 4.09E-07 1.69E-06 2.72E-07 1.75E-06 5.30E-07
trehaloseN 5.08E-06 9.10E-07 1.87E-04 5.06E-05 9.54E-05 2.70E-05 9.61E-04 2.13E-04
  1. E indicates essential amino acids; N indicates metabolites usually not observed in human cells.