Figure 6
From: Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum
NADPH balance for C. glutamicum lysCfbr (left) and its pyruvate kinase deficient derivative C. glutamicum lysCfbr Δpyk (right) considering glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase (PPP), isocitrate dehydrogenase (ICDH) and malic enzyme (MAE) as NADPH supplying reactions. Anabolism with a stoichiometric demand of 16.4 mmol NAPDH (g cell dry weight)-1 [27] and lysine production with a stoichiometric demand of 4 mol NADPH (mol lysine)-1 were considered as NADPH consuming reactions.