Analyte | Derivatization | Reagent |
---|---|---|
Alcohols | Silylation | trifluoroacetamides (BSA, MSTFA, BSTFA, MBDSTFA) |
Phenols | Acylation | activated carboxylates (ECF, TFAA) |
 | Alkylation | activated methyl groups (TMAH, TMSH, DMFDMA) |
Amines (primary, secondary) | Silylation | trifluoroacetamides (BSA, MSTFA, MSHFBA) |
 | Acylation | activated carboxylates (TFAA, HFBA, MBTFA) |
Amino acids | Silylation | trifluoroacetamides (MBDSTFA, BSA, BSTFA) |
 | Alkylation + Acylation | MeOH/TMCS, TMSH, DMFDMA + TFAA, HFBA, ECF, TFAA, |
Carboxylic Acids | Silylation | trifluoroacetamides (BSA, MSTFA, MSHFBA, TSIM) |
 | Alkylation | activated methyl groups (TMAH, TMSH, DMFDMA) |
a-keto acids | Oximation + Silylation | hydroxylamine, O-ethylhydroxylamine + trifluoroacetamides (BSA, MSTFA, BSTFA, MBDSTFA) |
Thiols | Acylation | activated carboxylates (ECF, TFAA) |
 | Alkylation | activated methyl groups (TMAH, TMSH, DMFDMA) |
Carbohydrates | Oximation + Silylation | hydroxylamine, O-ethylhydroxylamine + trifluoroacetamides (BSA, MSTFA, BSTFA) |
 | Silylation | trifluoroacetamides (BSA, MSTFA, BSTFA) |
 | Acylation | activated carboxylates (TFAA, MBDTFA) |