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Figure 3 | Microbial Cell Factories

Figure 3

From: Metabolic transcription analysis of engineered Escherichia coli strains that overproduce L-phenylalanine

Figure 3

Relative transcript levels for genes from carbon central metabolism for PB12 (first value) and PB13 (second value), as compared to JM101. Metabolic network showing the relative gene transcription levels of genes related to the carbon central metabolism, fermentative pathways and the connection with the common aromatic amino acid pathway. Most relevant transcriptional responses in host strains without plasmids are shown: PB12 (first value), PB13 (second value) as compared to JM101. According to the significance criterion, only those relative gene transcription values ≥ 2 (up-regulation, data in red) or ≤ 0.5 (down-regulation, data in blue), as compared to JM101 reference strain, are shown. The relative gene transcription value for JM101 is always equal to 1 and for that reason was omitted. No significant values were written in black. Metabolites abbreviations: GLC, glucose; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; PBP, fructose-1,6-biphosphate; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde 3-phosphate; 1,3-BGP, 1,3-biphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phophoglycerate; PEP, phosphoenolpyruvate; PYR, pyruvate; 6PGLN, 6-phosphoglucono-δ-lactone; 6PGNT, 6-phophogluconate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; Xu5P, xylulose-5-phosphate; S7P, sedoheptulose-7-phosphate; E4P, erythrose-4-phosphate; Ac-CoA, acetyl coenzyme A; Ac-P, acetyl phosphate; Ac-AMP, acetyl-AMP; CIT, citrate; ICT, isocitrate; GOX, glyoxylate; α-KG, α-ketoglutarate; SUC-CoA, succinyl-coenzyme A, SUC, succinate; FUM, fumarate; MAL, malate; OXA, oxaloacetate.

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