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Figure 1 | Microbial Cell Factories

Figure 1

From: Hitting bacteria at the heart of the central dogma: sequence-specific inhibition

Figure 1

Antisense inhibition mechanisms. An overview of the antisense inhibition mechanisms described in this review. AsRNA inhibition mechanism is thought to include steric hindrance of mRNA translation or rapid degradation of target RNA possibly by dsRNA-specific RNases. MPOs, PNAs and PMOs also inhibit expression by sterically blocking translation. ODNs and PS-ODNs induce cleavage of target RNA by RNase H, while EGSs guide RNase P in target RNA cleavage. Catalytic RNA or DNA cleaves the target RNA upon hybridization. See the text for details.

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