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Figure 3 | Microbial Cell Factories

Figure 3

From: Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis

Figure 3

Metabolic fluxes in C. glutamicum in growth and production phases of two different glutamate production activities. Dotted arrows indicate fluxes for biomass. Left, middle, and right values in boxes indicate fluxes in the growth and production phases, where glutamate fluxes were 20 and 68, respectively. In this study, the fluxes with backward (exchange) reactions, i.e., those in glycolysis, the pentose phosphate pathway, the latter steps of the TCA cycle (succinate → oxaloacetate), and C1 metabolisms, are shown as net values [22]. Abbreviations: Gly, glycine; Ser, serine; Glu, glutamate; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; FBP, fructose-1,6-bisphosphate; GAP, glyceraldehyde-3-phosphate; PEP, phosphoenolpyruvate; Pyr, pyruvate; Ru5P, ribulose-5-phosphate; R5P, ribose-5-phosphate; Xu5P, xylulose-5-phosphate; S7P, sedoheptulose-7-phosphate; E4P, erythrose-4-phosphate; AcCoA, acetyl-CoA; IsoCit, isocitrate; αKG, 2-oxoglutarate; Suc, succinate; Fum, fumarate; Mal, malate; Oxa, oxaloacetate.

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Microbial Cell Factories

ISSN: 1475-2859

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