Table 2 Glycation of antibody produced in 40L bioreactors and 1L spinners.
From: Cell culture efforts to reduce glycation in recombinant humanized antibody
Vessel | Volume | Clone | Harvest Time | Final [Glucose] | Glycation |
|---|---|---|---|---|---|
Bioreactor | 2 x 40L | 2 | Day 11 and Day 14 | > 9 g/L | 42% |
Bioreactor | 40L | 2 | Day 14 | > 10 g/L | 58% |
Bioreactor | 40L | 2 | Day 14 | > 7 g/L | 42% |
Spinner | 1L | 2 | Day 5 | < 6 g/L | 13% |
Spinner | 1L | 191 | Day 5 | < 6 g/L | 11% |