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Table 1 Summary of main conclusions

From: Evaluation of antifoams in the expression of a recombinant FC fusion protein in shake flask cultures of Saccharomyces cerevisiae &Pichia pastoris

Antifoam name

Antifoam type

Pichia pastoris

Saccharomyces cerevisiae

  

Growth

Production

Growth

Production

SB2121

Polyalkylenglycol

No effect < = 8% [SB2121]

No effect < = 8% [SB2121]

Optimal when [SB2121] >0% <4%

Decreased by [SB2121] >1%

J673A

Alkoxylated fatty acid ester on a vegetable base

Increases with [J673A]

Decreased by [J673A] >1%

Increases with [J673A]

Decreased by [J673A] >1%

Antifoam C

Siloxane polymer

No effect < = 8% [Antifoam C]

TBC

No effect < = 8% [Antifoam C]

TBC

P2000

Polypropylene glycol

Decreased by [P2000] >1%

TBC

Increases with [P2000]

TBC