Table 1 Effect of PrsA, dlt mutation and depletion of HtrA proteases on secretion of heterologous proteins studied.
Protein and origin | PrsA dependency | PrsA Over- expression | Dlt mutation | Depletion of HtrA protease |
|---|---|---|---|---|
α-amylase (B. stearothetmophilus) | yes(+) | ↑ | no effect | ↓ |
β-glucanase (B. licheniformis) | no | no effect | ||
Penicillinase (B. licheniformis) | no | no effect | no effect | |
Pneumolysin (S. pneumoniae) | yes(+) | ↑ | ↑ | ↓ |
Diphteria toksoid (C. diphteriae) | no | no effect | ||
Staphylokinase (S. aureus) | yes(-) | |||
Pectinase (E. carotovora) | yes(+) | ↓ | ↓ | no effect |
Pectin methylesterase (E. chrysanthemi) | no | no effect | no effect | |
β-lactamase (E. coli) | yes(+) | no effect | ↓ | |
Pertussis toxin S1 (B. pertussis) | no | ↓ | ↓ | ↓ |
Pertussis toxin S4 (B. pertussis) | no |