Regulation of methanol utilisation pathway genes in yeasts

Table 2 Repression and derepression effect of carbon sources on AOX genes of methylotrophic yeasts.

		Glucose, EtOH	Glycerol	Methanol	Glycerol+MeOH
P. pastoris [61, 62, 83, 92, 93]	AOX1	Repression	Repression	Induction	Repression
	AOX2	Repression	Repression	Induction	Repression
H. polymorpha [76, 88–91]	MOX	Repression	Derepr. (~60–70%)	Induction	Induction (~100%)
	FMD	Repression	Derepr. (~60%)	Induction
C. boidinii [57, 68, 70, 71, 86, 87]	AOD1	Repression	Derepr. (~3–30%)	Induction	Induction (~90%)
	FLD	No activity	Derepr. (~20%)	Induction	Induction (~70%)
	FDH	Repression	No activity	Induction	Induction (~30%)
	DAS	Repression	Derepr. (~2%)	Induction	Induction (~70%)
P. methanolica [78, 82, 100, 101]	MOD1	Repression	Derepr. (~60–70%)	Induction	Induction (~100%)
	MOD2	Repression	No activity	Induction	Induction (~100%)
	FLD	No activity	Derepr. (~20%)	Induction	Induction (~70%)

Effect and level of derepression compared to the methanol induced level are shown (Induction by methanol for each gene denotes 100%). The data was extracted from the literature given by the citations and are taken from experiments were ammonia was used as nitrogen source.