Table 2 Model parameters for rifamycin B " fermentation using the strain Amycolatopsis mediterranei^a

Amino acids

μ ₁ ^max

Ks₁

k _NT1

K_I1

μ ₂ ^max

Ks₂

K_I2

Ks_2,2

K_I2,2

k _NT2

Kp₂

K_{pI 2}

K_{p2 2}

K_pI2,2

$K_{E{1}_i}$

Alanine

0.0015

0.0016

0.0259

0.0158

0.0386

2 × 10^-6

0.51

0.000155

0.0929

0.5929

1.12 × 10^-5

0.0112

0.1124

1.1236

7.782 × 10^-05

Glycine

0.0241

0.0004

0.8507

0.1551

0.02

0.003866

0.1543

0.003866

0.1507

0.1507

1.33 × 10^-5

0.0133

0.1333

1.3333

0.001899

Valine

0.0001

5.15 × 10^-6

0.5671

0.4738

0.02

5.15 × 10^-6

0.4382

5.15 × 10^-6

0.5671

0.5671

8.55 × 10^-6

0.0085

0.0855

0.8547

8.963 × 10^-06

Leucine

0.0004

9.5 × 10^-6

0.0387

0.1583

0.024

1.56 × 10^-5

0.7835

1.56 × 10^-5

0.4888

0.0387

7.63 × 10^-6

0.0076

0.0763

0.7634

4.137 × 10^-05

Isoleucine

0.0057

2.88 × 0^-5

0.0323

0.0008

0.0487

2.88 × 10^-5

0.3545

0.00082

0.1783

0.1783

8.4 × 10^-6

0.0076

0.0763

0.7634

0.0004403

Threonine

0.0486

0.0011

0.1649

0.0018

0.0259

0.002746

0.5618

0.00171

0.1649

0.1649

9.52 × 10^-6

0.0084

0.084

0.8403

0.0031509

Serine

0.0191

0.0187

0.6791

0.1634

0.045

0.018685

0.936

0.00018

0.01

0.6791

8.7 × 10^-6

0.0095

0.0952

0.9524

0.0014994

Proline

0.0101

0.0071

0.1103

0.092

0.06

3.0 × 10^-4

0.45

0.00057

0.9103

0.9103

7.52 × 10^-6

0.0087

0.087

0.8696

4.724 × 10^-06

Aspertic acid

0.0106

5.17 × 10^-7

0.0272

0.9714

0.052

0.05171

0.0271

5.17 × 10^-9

0.1609

0.1609

6.71 × 10^-6

0.0075

0.0752

0.7519

0.0085576

Methionine

0.0091

0.0007

0.0476

0.0404

0.1

7.42 × 10^-5

0.9429

0.00142

0.0007

0.4758

6.8 × 10^-6

0.0067

0.0671

0.6711

6.855 × 10^-05

Glutiamic acid

0.0075

0.0006

0.4581

0.1383

0.075

0.013622

0.0283

1.36 × 10^-5

0.3058

0.3058

6.06 × 10^-6

0.0068

0.068

0.6803

0.0018939

Phenylalanine

0.0042

2.26 × 10^-5

0.0082

0.045

0.0602

2.26 × 10^-6

0.925

2.26 × 10^-6

0.0419

0.0082

6.84 × 10^-6

0.0061

0.0606

0.6061

6.98 × 10^-05

Glutamine

0.0001

3.59 × 10^-5

0.033

0.0068

3.51 × 10^-5

3.59 × 10^-5

0.0007

3.59 × 10^-5

0.033

0.033

6.85 × 10^-6

0.0068

0.0684

0.6845

5.523 × 10^-07

Lysine

0.0109

1.62 × 10^-7

0.0636

0.0581

0.0798

0.016222

0.013

0.00015

0.8362

0.8362

6.45 × 10^-6

0.0068

0.0685

0.6849

0.0040591

Histidine

0.0157

8.79 × 10^-6

0.0472

0.0942

0.0685

8.79 × 10^-9

0.4009

8.79 × 10^-6

0.7243

0.7243

5.52 × 10^-6

0.0065

0.0645

0.6452

0.0036322

Tyrosine

0.0116

0.0001

0.0567

0.0151

0.0722

0.000151

0.5095

0.00015

0.0367

0.0367

4.9 × 10^-6

0.0065

0.0552

0.5525

0.0016529

Tryptophan

0.3919

1.49 × 10^-5

0.0241

0.0049

0.0392

1.49 × 10^-7

0.4902

1.49 × 10^-5

0.0241

0.0241

8.7 × 10^-16

0.0049

0.049

0.4902

0.0100978