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Table 4 Safety concerns of the antigen encoding sequence

From: Live bacterial vaccines – a review and identification of potential hazards

For protein and DNA vaccines Transfer of undesired genes via plasmid
  Transfer of vector to indigenous flora
  Open reading frames coding for injurious peptides (allergens)
  Imprecise transcription and translation
Specifically for DNA-vaccines Persistence of DNA
  Permanent expression of the foreign antigen
  Formation of anti-DNA antibodies
  Transformation event
  Spread of antibiotic resistance genes