Table 4 Safety concerns of the antigen encoding sequence
From: Live bacterial vaccines – a review and identification of potential hazards
For protein and DNA vaccines | Transfer of undesired genes via plasmid |
Transfer of vector to indigenous flora | |
Open reading frames coding for injurious peptides (allergens) | |
Imprecise transcription and translation | |
Specifically for DNA-vaccines | Persistence of DNA |
Permanent expression of the foreign antigen | |
Formation of anti-DNA antibodies | |
Transformation event | |
Spread of antibiotic resistance genes |