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Table 1 Attenuated bacteria as vaccine vehicles

From: Live bacterial vaccines – a review and identification of potential hazards

Vaccine strain

Attenuation

Foreign insert

Model

Ref.

Shigella flexneri

Δasd

pCMVβ

Guinea pig, in vitro

[80]

 

Δasd

CS3 and LTB/STm

Mouse

[81]

 

Δrfb F

HIV-1 SF2Gag

Mouse

[17]

 

Δdap A Δdap B

β-gal, gene vaccine

In vitro

[16]

 

Δaro A Δisc A

gp120, gene vaccine

Mouse

[15]

Salmonella enterica

Δaro A

pCMVβ, pCMVact A and pCMVhly

In vitro, mouse

[82]

 

Δaro A Δaro D

C. tetani TTFC

Mouse

[83]

 

Δaro A Δhtr A

TTFC

Mouse

[83]

 

Δaro A+others

GFP+cytokines

Mouse

[84]

 

Δcya Δcrp Δasd

SP10 cDNA

Mouse

[20]

 

Gal E + unspecified

H. pylori, ure AB

Human

[85]

Yersinia enterocolitica

pYV-

B. abortus, P39

Mouse

[86]

 

pYV-

Ova

Mouse

[87]

Listeria monocytogenes

Δact A

Leichmania major

Mouse

[88]

 

Δact A

LCM virus

Mouse

[89]

 

Δdal Δdat

HIV-1 gag gene vaccine

Mouse

[90]

 

Δ2

M. bovis gene vaccine

Mouse

[91]

Bordetella bronhiseptica

Δaro A

TTFC

Mouse

[92]

Erysipelotrix rhusiopatie

Tn916-

M. hyopneumonie

Mouse, pig

[93]

Mycobacterium bovis

unspecified

P. falciparum, CSP

Mouse

[94]

Brucella abortus

Rough mutant (O-)

lac Z or HSP65

Mouse

[95]