Figure 9
From: Enzymes: An integrated view of structure, dynamics and function
A schematic representation of the integrated view of enzyme structure, dynamics and function. Enzyme structure and internal protein dynamics events play a role in the catalytic step. Conserved residues from the surface to the active-site participate in network of protein motions or vibrations that promotes catalysis. The surface residues are coupled to the thermo-dynamical fluctuations of the solvent, and possibly play a role in transfer of energy from solvent to the protein.