Figure 4
From: Enzymes: An integrated view of structure, dynamics and function
Genomic analysis for sequence conservation of CypA. Full analysis was performed on 50 sequences from species ranging from bacteria to human, results from 10 representative sequences are listed above. 17 of 165 amino acid residues in the human CypA sequence were found to be conserved in all 50 PPIases sequences examined: Pro30; Asn35; Phe36; Phe53; His54; Arg55; Ile57; Phe60; Gln63; Gly65; Glu86; Met100; Gln111; Phe112; Phe113; Leu122; and Phe129. Eight additional residues were found to be strongly conserved: Thr32; Tyr48; Met61; Phe83; Leu98; Thr107; Ile114 and His126. Five other residues were found to be weakly conserved: Phe22; Val29; Asn102; Ser110 and Gly130. Conserved active-site residues (fully conserved Arg55, Phe60, Leu122; strongly conserved His126**; and weakly conserved Asn102*) are shown with green background. Red background shows fully conserved residues distal to the active-site; residues with cyan background are strongly conserved; and residues with yellow background are weakly conserved.