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Table 1 Overview of various applications of the NICE system

From: Optimization of the Lactococcus lactis nisin-controlled gene expression system NICE for industrial applications

Application area

Application

Reference

Expression of homologous genes

Aminopeptidase N

[7]

 

ATPase system (8 gene operon)

[28]

 

Aminoacylase

[29]

 

Cluster of genes encoding folate biosynthesis

[19]

Expression of heterologous genes of Gram+ and Gram- bacteria

NADH oxidase of Streptococcus mutans

[30]

 

Fructose bisphosphatase of Escherichia coli

[31]

 

Green fluorescent protein of Aequoria victoria

[32]

 

Lysostaphin of Staphylococcus simulans biovar. Staphylolyticus

[15]

Protein secretion

Lipase of Staphylococcus hyicus

[33]

 

Bovine beta-lactoglobulin

[34]

Membrane proteins: prokaryotic and eukaryotic

Multidrug transporter of Lactococcus lactis

 
 

Xylidose transporter of Lactobacillus pentosus

 
 

ATP/ADP translocator of Rickettsia prowazekii

Review [35]

 

KDEL receptor of Homo sapiens

 
 

Mitochondrial carriers of Saccharomyces cerevisiae

 

Cloning of toxic genes

Lysis cassette of the virulent phage us3 of

[26]

 

Lactococcus lactis

 
 

Autolysin gene of Leuconostoc citreum

[36]

Bacterial antigens

Antigen L7/12 of Brucella abortus

[13, 37]

 

C subunit of tetanus toxin (TTFC) of Clostridium tetani

[38]

Viral antigens

Non-structural protein 4 of bovine rotavirus

[13, 39]

Cytokines

Interleukin 12 of Homo sapiens

[40]

Industrial-scale application

Lysostaphin of Staphylococcus simulans biovar. Staphylolyticus

[15]