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Table 6 Differentially expressed genes of the biosynthetic pathways of methionine and other amino acids for which significant values were obtained (Symbols are as for table 4)

From: Differential gene expression in recombinant Pichia pastoris analysed by heterologous DNA microarray hybridisation

Metabolic Pathway

Common Gene Name

pH 5

pH 3

 

Methionine

MET3

â–²

â–²

ATP sulfurylase

 

MET16

â–²

â–² tend.

3'-phosphoadenylsulfate reductase

 

MET17

â–²

â–²

O-acetyl homoserine-O-acetyl serine sulfhydrylase

 

MET6

â–¼

â–¼

methionine synthase

 

SAM1

â–¼

—

S-adenosylmethionine synthetase

 

SAM2

â–¼

â–¼

S-adenosylmethionine synthetase

 

SAH1

â–¼

â–¼

putative S-adenosyl-L-homocysteine hydrolase

Amino acid biosynth.

AAT2

â–¼

â–²

aspartate transaminase

 

ARG1

—

â–¼

arginine biosynthesis

 

ILV5

—

â–¼

branched-chain amino acid biosynthesis

 

LPD1

â–¼

—

serine biosynthesis