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Table 2 Bacteriocin classification with representative bacteriocins isolated in our laboratory.

From: Novel bacteriocins from lactic acid bacteria (LAB): various structures and applications

Class Features Examples (Reference)
I Lantibiotics, small (<5 kDa) peptides containing lanthionine and β-methyllanthionine Nisin Z [77] and Q [31], Enterocin W [78],
Nukacin ISK-1 [79]
II   Small (<10 kDa), heat-stable, non-lanthionine-containing peptides  
  IIa Small heat-stable peptides, synthesized in a form of precursor which is processed after two glycine residues, active against Listeria, have a consensus sequence of YGNGVXC in the N-terminal Enterocin NKR-5-3C [35, 36], Enterocin A [80],
Munditicin [81],
Leucocin A [80]
  IIb Two component systems: two different peptides required to form an active poration complex Lactococcin Q [43],
Enterocin NKR-5-3AZ [36],
Enterocin X [44]
  IIc N- and C- termini are covalently linked, resulting in a circular structure Lactocyclicin Q [49], Leucocyclicin Q [50]
  IId Other class II bacteriocins, including sec-dependent bacteriocins and leaderless bacteriocins Lacticin Q [22] and Z [54], Weissellicin Y and M [55], Leucocin Q and N [80]
III Ϯ   Large molecules heat sensitive peptides  
  1. Ϯ suggested to be renamed Bacteriolysins .