From: Novel nikkomycin analogues generated by mutasynthesis in Streptomyces ansochromogenes
Position | Nikkomycin Px | Nikkomycin Pz | ||
---|---|---|---|---|
δ (1H, mult., J) | 13C (δ) | δ (1H, mult., J) | 13C (δ) | |
2 | Â | 153.4 | Â | 151.4 |
4 | Â | 124.1 | Â | 166.0 |
5 | 7.53 (1H, s) | 125.5 | 5.74 (1H, d, 8.1) | 102.4 |
6 | 9.16 (1H, s) | 180.3 | 7.42 (1H, d, 8.1) | 142.5 |
1´ | 5.53 (1H, d, 4.5) | 87.7 | 5.65 (1H, d, 4.2) | 91.2 |
2´ | 4.43 (1H, dd, 4.5, 5.5) | 72.3 | 4.29 (1H, dd, 4, 6) | 72.2 |
3´ | 4.52 (1H, t, 5.5) | 70.1 | 4.42 (1H, t, 6) | 69.8 |
4´ | 4.25 (1H, dd, 4.0, 5.5) | 82.3 | 4.17 (1H, dd, 3.5, 6.5) | 82.0 |
5´ | 4.74 (1H, d, 4.0) | 54.3 | 4.73 (1H, d, 4) | 54.3 |
6´ |  | 171.2 |  | 171.3 |
1´´ |  | 168.9 |  | 168.9 |
2´´ | 4.36 (1H, d, 4) | 57.0 | 4.35 (1H, d, 4) | 56.9 |
3´´ | 2.36 (1H, m) | 40.2 | 2.55 (1H, m) | 39.6 |
4´´ | 5.37 (1H, s) | 71.3 | 5.36 (1H, s) | 71.3 |
5´´ | 0.68 (3H, d, 7) | 5.11 | 0.67 (1H, d, 7.1) | 5.05 |
2´´´ | 8.7 (1H, s) | 138.5 | 8.68 (1H, s) | 138.6 |
3´´´ |  | 142.8 |  | 142.7 |
4´´´ | 8.49 (1H, d, 8.2) | 144.4 | 8.46 (1H, d, 8.2) | 144.3 |
5´´´ | 7.97 (1H, dd, 8.1, 6) | 127.1 | 7.94 (1H, dd, 8.1, 5.9) | 127.1 |
6´´´ | 8.62 (1H, d, 5.5) | 140.3 | 8.60 (1H, d, 5.7) | 140.3 |