Carbon source dependent promoters in yeasts

Weinhandl, Katrin; Winkler, Margit; Glieder, Anton; Camattari, Andrea

doi:10.1186/1475-2859-13-5

Microbial Cell Factories

Table 3 Yeast promoters derepressed by gradual glucose consumption (repressed by glucose), and respective known regulator elements and binding sites

From: Carbon source dependent promoters in yeasts

Promoter	Protein function	Organism	Derepressed by: (strength)	Regulating sequence	DNA-binding target protein	Ref.
HXT7	High affinity hexose transporter	S. cerevisiae	Low glucose level (10-15×)	No information available		[25][26]
HXT2	High affinity hexose transporter	S. cerevisiae	Low glucose level (10-15×)	-590 to -579	Rgt1	[27][28]
				-430 to -424
				-393 to -387
				-504 to -494	Mig1	[27]
				-427 to -415	Mig1	[27]
				-291 to -218	UAS	[29]
				-226 to -218	Activator protein?	[29]
HXT4	High affinity hexose transporter	S. cerevisiae	Low glucose level	-645 to -639	Rgt1	[28]
HXT6	High affinity hexose transporter	S. cerevisiae	Low glucose level (10×)	No information available	Mig2	[10]
KHT2	High affinity hexose transporter	K. lactis	Low glucose level (2×)	No information available		[30]
HGT9, 10, 12, 17	High affinity hexose transporter	C. albicans	Low glucose level	No information available		[31]
SUC2	Invertase	S. cerevisiae	Sucrose low glucose level (200×)	-499 to -480	Mig1/2	[20]
				-442 to -425	Mig1/2
				-627 to -617	Sko1
				-650 to -418	UAS
				-133	RNA-Pol II
ADH2	Alcohol dehyrogenase	S. cerevisiae	Low glucose level (100×)	-319 to -292	Cat8	[24]
ADH2	Alcohol dehyrogenase	S. cerevisiae	Low glucose level (100×)	-291 to ??	Adr1	[24]
JEN1	Lactate permease	S. cerevisiae	Low glucose level (10×), lactate	-651 to -632	Cat8	[21][32]
				-1321 to -1302	Cat8	[21][32]
				-660 to -649	Mig1	[32]
				-1447 to -1436	Mig1	[32]
				-739 to -727	Abf1	[32]
MOX	Methanol oxidase	H. polymorpha	Low glucose level, glycerol	-245 to -112	Adr1	[33]
MOX	Methanol oxidase	H. polymorpha	Low glucose level, glycerol	-507 to -430	UAS	[34]
AOX delta 6	Alcohol oxidase	P. pastoris	Low glucose level, glycerol		deleted GCR1-site	[33]
GLK1	Glucokinase	S. cerevisiae	Low glucose level (6×), ethanol (25×)	-881 to -702	Gcr1	[35]
				-572 to -409	URS
				-408 to -104	Msn2/4
HXK1	Hexokinase	S. cerevisiae	Low glucose level (10×), ethanol	No information available		[36]
ALG2	Isocitrate lyase	H. polymorpha	Low glucose level	No information available		[37]

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ISSN: 1475-2859

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