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Figure 6 | Microbial Cell Factories

Figure 6

From: Exometabolome analysis reveals hypoxia at the up-scaling of a Saccharomyces cerevisiae high-cell density fed-batch biopharmaceutical process

Figure 6

Pathway diagram and corresponding heat map table and line plot graphs showing biochemical differences in the intermediates of the mevalonate/ergosterol pathway between scales. (A) Line plot graphs comparison between two scales. (B) Pathway diagram comparison between two scales. (C) Heat map table comparison between two scales. Red and green arrows show changes in the 10,000 L scale with respect to that at the 10 L scale. The intermediates measurement and data analysis were determined as described in “Methods”. Error bars represent “mean +/− one standard deviation”. “M” and “F” in the time axis for every line plot stand for Medium and Feed samples, respectively.

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