Figure 3From: Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa Scheme of metabolic pathways where enzymes upregulated in specific growth phase during antibiotic production are highlighted. Enzymes related to the synthesis of spinosad precursors were in red rectangles; the enzymes were underlined when the total PAI value more than 3 which revealed it is a abundant protein in S. spinosa proteome. Black dot indicated a enzyme owned a peak in T2 when compared to other three phases; black triangle signified a protein up-regulated in T2, T3 and T4 while compared to T1 and had a peak in T4. Reactions are reported according to KEGG metabolic pathway databases and Gallo et al. [10]. Enzyme name abbreviations refer to Additional file 3: Table S5.Back to article page