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Figure 3 | Microbial Cell Factories

Figure 3

From: Disruption of rimP-SC, encoding a ribosome assembly cofactor, markedly enhances the production of several antibiotics in Streptomyces coelicolor

Figure 3

Effects of rimP-SV disruption on biomass and jadomycin B production. (A) Growth curve of the S. venezuelae wild-type strain (WT), rimP-SVDM and rimP-SVDMC with ethanol (ET) induction. Biomass was calculated by mycelium dry weight. (B) The yield of jadomycin B (JdB) in WT, rimP-SVDM and rimP-SVDMC. (C) HPLC analyses of fermentation filtrates from WT, rimP-SVDM and rimP-SVDMC grown for 48 h. mAU, milli absorbance units. (D) Transcriptional analysis of jadomycin B biosynthetic gene cluster by RT-PCR. Total mycelial RNA extracted after 24 h fermentation was used as template.

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Microbial Cell Factories

ISSN: 1475-2859

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